MONARGAN

MONARGAN 50mg

 

What is this medicine?

MONARGAN 50 mg contains promethazine hydrochloride, a first-generation antihistamine with sedative and antiemetic properties. It’s used to treat allergies (including hay fever and urticaria), prevent or relieve motion sickness, manage nausea and vomiting (e.g. post-surgery), and as a short-term sleep aid or sedative before procedures.

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What should I tell my health care provider before I take this medicine?

Inform them if you have any of these conditions:

• Allergy to promethazine or any inactive ingredient (e.g., lactose, dyes)

• Age under 2 years – contraindicated due to risk of fatal respiratory depression

• Respiratory issues (asthma, COPD, sleep apnea), liver or kidney disease

• Glaucoma, enlarged prostate or urinary retention, GI obstruction

• Seizures or epilepsy (may lower seizure threshold)

• Bone marrow depression

• History of neuroleptic malignant syndrome

• Taking sedatives, opioids, barbiturates, MAOIs, or central depressants

• Pregnant or breastfeeding — discuss risks and benefits

Also tell them about any:

• Alcohol use (can worsen drowsiness)

• Other medications, herbs, supplements you take (risk of interactions).

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How should I use this medicine?

• Adults & children ≥10 years: 50 mg orally, typically at bedtime for sedation or 1–2 hours before travel to prevent motion sickness. Can be repeated nightly for short-term use.

• Nausea/Vomiting: 25–50 mg every 4–6 hours as needed.

• Allergies/hives: 25 mg at bedtime or 12.5 mg before meals & at bedtime (max 25–50 mg/day).

• Follow your provider’s instructions for dose and duration.

• Overdose: Seek emergency help—signs include extreme drowsiness, seizures, breathing problems, coma.

• Do not share this medicine.

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What if I miss a dose?

• For scheduled use (e.g. nightly dose): take it as soon as you remember unless next dose is near—then skip and continue normally.

• Do not double the dose.

• For single-use doses (e.g., motion sickness): skip if time has passed and resume next time.

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What may interact with this medicine?

• CNS depressants: sedatives, opioids, alcohol—additive drowsiness and respiratory depression

• MAO inhibitors (or within 14 days): risk of severe sedation/side effects

• Anticholinergic drugs: increased dryness, blurred vision, urinary retention

• Antihypertensives: may worsen hypotension

• Seizure medications: promethazine lowers seizure threshold

• Many other drug interactions – review all meds with your provider.

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What should I watch for while using this medicine?

• Avoid driving or operating machinery until fully alert—it can cause sedation lasting up to 12 hours.

• Monitor respiratory function if you have lung problems or in young children.

• Watch for signs of worsening glaucoma, urinary retention, constipation.

• Be alert for seizure activity if you have epilepsy.

• In elderly patients, cognitive impairment and falls may occur—use cautiously.

• Avoid prolonged use—consult doctor if symptoms persist beyond a week.

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What side effects may I notice from this medicine?

Serious – report immediately:

• Allergic reactions: rash, swelling, breathing difficulty

• Respiratory depression, especially in children under 2 or with compromised lungs

• Irregular heartbeat, low blood pressure, palpitations

• Extrapyramidal symptoms: uncontrolled movements, muscle rigidity

• Neuroleptic malignant syndrome: high fever, muscle stiffness, confusion

• Bone marrow suppression: signs of anemia, infection

• Seizures or changes in mental status

Common mild side effects:

• Drowsiness, dizziness, confusion, dry mouth, blurred vision, constipation, urinary retention

• Light sensitivity—use sunscreen and avoid sun exposure

• Low blood pressure when standing—be cautious getting up quickly

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Where should I keep my medicine?

• Store in original container, protected from light and moisture, at room temperature (20–25 °C / 68–77 °F).

• Keep out of reach of children.

• Discard unused medicine after the expiration date.